Although all ABO groups are acceptable for cryo infusion, does anyone have a policy that states a maximum amount of ABO incompatible product that may be infused?

As a children's hospital, we give any ABO type (of any volume) to patients over 4 months of age. Neonates under 4 months get ABO plasma-compatible cryo.

This is in-line with the AABB Technical Manual, 17th ed. (pg 657) - "Although cryoprecipitate transfusions in adults are not required to be ABO compatible with the recipient, these components should be ABO compatible with neonatal recipients because of their smaller blood volumes."

The current Circular of Information, however, states that "ABO compatible material is preferred".

Stephanie