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Auto anti-D in pregancy

Rhona24
in Immunohematology Reference Laboratories

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comment_44731

We have a 35 year old obstetric patient (CCDee, weakly pos DAT (IgG) ) who is 11 weeks pregnant with an apparent auto anti-D. She has had 2 previous misscarriages. After the second miscarraige she had a warm free auto antibody reacting with all cells but when titred out showed anti-D specificity. Anti-D was eluted from her red cells.

Has anyone else encountered this?

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comment_44753

Yes, but two things.

I don't think that the true specificity is auto-anti-D, but a mimicking auto-anti-D.

I have doubts that the two miscarriages are involved with the antibody.

comment_44793
Yes, but two things.

I don't think that the true specificity is auto-anti-D, but a mimicking auto-anti-D.

I have doubts that the two miscarriages are involved with the antibody.

Malcom how would one determine if this auto-Anti D was involved or not?

comment_44806

If it were a true auto-anti-D, no matter how many times you adsorb the plasma with rr red cells, the anti-D would not adsorb out.

If it were a mimicking auto-anti-D, it would be adorbed out eventually with rr red cells.

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