We have a donor who was a previous patient and has Anti-Yta,-Fya. We have to redemonstrate the previous antibody and rule out common alloantibodies every time the donor comes in. My question is, if we rule out the common alloantibodies by adsorption (redemonstrating the Fya) and the neat panel is positive (negative auto control) demonstrating the Yta, do we also have to run the Yta and Fya negative cell everytime to prove it is indead the Yta and not some other high incidence antibody? I just worry that we may run out of the rare cell as this donor is in frequently. Just curious for other opinions!

Thanks!!!!!!!!!

I wouldn't run it every time.

If he( she) is a donor, we will discard the plasma and wash the cells, because the antibody will add some difficult to the recipient.

You do not have to run the Yta and Fya negative cell every time. You are keeping (archiving) the results and even if the antibodies are no longer detectable you still honor the history.