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comment_34257

I am trying to interpret the requirements for antigen-antibody testing and compatibility testing of autologous units in the 26th edition (5.12 to 5.15.3) of the AABB Standards. The way the information is organized leads to differing thoughts on how the information is interpreted

Questions:

1. Do autologous units require antigen confirmation to a patient's corresponding antibody?

2. Do autologous units require a serological crossmatch when the patient has a clinically significant antibody or a positive antibody screen?

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comment_34263

I read the Standards to say that only ABO/Rh confirmation of the unit and patient are necessary before transfusion of Autolous blood (Standards 5.12 and 5.13.4) We do antigen typing on the donor/patient as part of the pretransfusion workup (we treat autologous patients just like everyone else as far as type and screen and antibody identification testing because they could require more blood later). We either antigen type or Coombs crossmatch the unit just to ensure that we have a match. I believe this is more than what is required by Standards.

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