If this is accurate, there's 21 and the year is 1955--that's where I got the info:

http://en.wikipedia.org/wiki/Diego_antigen_system

Actually, the Diego Blood Group System is another one with a slightly quirky history.

Anti-Dia was first described in 1955 (Layrisse M, Arends T, Dominguez Sisico R. Nuevo grupo saguineo encontrado en descendientes de Indios. Acta Med Venezolana 1955; 3: 132-138 - I must admit to not having read this one), but anti-Wra (now Wr(a) is the third antigen in the Diego Blood Group System) was actually described in 1953 (Holman CA. A new rare human blood-group antigen (Wr[a]). Lancet 1953; ii: 119).

It's a bit like the situation with the Kell Blood Group System and anti-Levay (now anti-Kpc), which was actually described before anti-K!

Dead easy this blood group nomenclature stuff (I don't think)!!!!!!!!

:eek::cries::(

OK, I'll take a stab at this one. The why has to be because of the absence of the glycosylphosphtidylinositol that would form the anchor for the rest of the antigen. The antigens affected are Cromer, YT, Holley-Gregory, JMH, and Dombrock.

Wow, that one was hard!

In the same vein, what other hematologic disease are PNH patients more susceptible for?

Well, as a pure (maybe slightly soiled) blood group serologist, this one has got me stumped. My knowledge of haematology is woeful.

As nobody else seems to have answered either, what is the answer adiescast?

Of course, you'll then have to set another (blood transfusion related) question!!!!!!!!!!!!!!!!!

:confused::eek:

What about Myelodysplastic Syndrome? (answer for adiescast question)

leukemia, thrombosis,Aplastic anemia

leukemia, thrombosis,Aplastic anemia

These are all correct.

I'm sorry you didn't like my question, Malcolm. I don't have another to hand...could someone restart things, please?

We need another question now.

Sorry for being late.

My question is 'Why doesn't enzyme destroy Fy3 and Fy5 but Fya and Fyb?'

Cheers

leukemia, thrombosis,Aplastic anemia

Is there Leukemia??? I'm confused since I know PNH patient has triad of hemolysis, thrombosis and bone marrow failure (pancytopenia).

Can any one help?

:confused:

These are all correct.

I'm sorry you didn't like my question, Malcolm. I don't have another to hand...could someone restart things, please?

Whoo, whoo, hold on! I didn't say I didn't like your question. I have learned from it (and that is the point). WHat I said was that I didn't have a clue and that my haematology is woeful. That is an admission of fault on my behalf; not a criticism of your question in any way! I'm very sorry if it sounded like that; it was not meant as such.

:redface::redface:

What was unique about anti-Fy6 when it was first described (and may still be, for all I know)?

:confused::confused:

Edited June 26, 201015 yr by Malcolm Needs

Dear han,

PNH is rare, with an annual rate of 1-2 cases per million. Many cases develop in people who have previously been diagnosed with aplastic anemia or myelodysplastic syndrome. The fact that PNH develops in MDS also explains why there appears to be a higher rate of leukemia in PNH, as MDS can sometimes transform into leukemia,you can have a look at :

*Coexistence of paroxysmal nocturnal hemoglobinuria (PNH) and acute lymphoblastic leukemia (ALL): Is PNH a prodrome of ALL?(Leukemia research,vol 33,issue 33,pages e3-e5 (March 2009)

*Mayo Clinic Internal Medicine Review: Eighth Edition By Amit K. Ghosh, page 422.

*Coexistence of paroxysmal nocturnal hemoglobinuria and chronic lymphocytic leukemia,American Journal of Hematology,Volume 11 Issue 4, Pages 439 - 441

Dear han,

PNH is rare, with an annual rate of 1-2 cases per million. Many cases develop in people who have previously been diagnosed with aplastic anemia or myelodysplastic syndrome. The fact that PNH develops in MDS also explains why there appears to be a higher rate of leukemia in PNH, as MDS can sometimes transform into leukemia,you can have a look at :

*Coexistence of paroxysmal nocturnal hemoglobinuria (PNH) and acute lymphoblastic leukemia (ALL): Is PNH a prodrome of ALL?(Leukemia research,vol 33,issue 33,pages e3-e5 (March 2009)

*Mayo Clinic Internal Medicine Review: Eighth Edition By Amit K. Ghosh, page 422.

*Coexistence of paroxysmal nocturnal hemoglobinuria and chronic lymphocytic leukemia,American Journal of Hematology,Volume 11 Issue 4, Pages 439 - 441

Dear Mania

Thanks for your useful information and the references. I'll read them.

Cheers

What was unique about anti-Fy6 when it was first described (and may still be, for all I know)?

:confused::confused:

That it has never been produced by a human! And I think that is still the case.

Now if I have that correct, sticking with Fy, my question is...

Which ancient tribe of people (still in existence but only just!) with a high proportion phenotyping as Fy(a-b-) are thought to have originated out of Africa ~60,000 years a go & be the ancestors of the indigenous Papua New Guineans & Australian aborigines? Clue: they inhabit a group of islands between Africa & PNG!!

That it has never been produced by a human! And I think that is still the case.

Now if I have that correct, sticking with Fy, my question is...

Which ancient tribe of people (still in existence but only just!) with a high proportion phenotyping as Fy(a-b-) are thought to have originated out of Africa ~60,000 years a go & be the ancestors of the indigenous Papua New Guineans & Australian aborigines? Clue: they inhabit a group of islands between Africa & PNG!!

Perfectly correct!

As for your question, I think I'll ask my Mum. I think she was around in those days!!!!!!!!

:redface::tongue::tongue::rolleyes:

Now that's just mean!!

Ok--I'll try to answer Fluffy's question: the tribe is the Jarawas?

http://en.wikipedia.org/wiki/Duffy_antigen_system

Absolutely spot on LisaM!

The paper reference is:

The Duffy blood groups of Jarawas - the primitive and vanishing tribe of Andaman and Nicobar Islands of India. M.K. Das et al. Transfusion Medicine, 2005, 15, 237-240.

I just wish that they had gone on to do molecular work too, this would have shown whether their mutation is carried on FYA or FYB. This could then possibly show that both mutations actually originated in Africa aroound the same time.

I would also like to know if there has been any Duffy typing done on the Australian aborigine population. So far I haven't been able to find any published work.

I find Duffy fascinating when used as an ancestral marker.

Your turn for a new question I do believe...!

Yay! I finally got one right--lol lol!

Here's the next question: In addition to humans, what type of animal would you also find ABO blood groups in?

Stab in the dark here... primates?

Yay! I finally got one right--lol lol!

Here's the next question: In addition to humans, what type of animal would you also find ABO blood groups in?

I'm not going to spoil it all yet by giving an aswer, but your question did just remind me of a lovely bit in the 6th Edition of Rob Race and Ruth Sanger's book, Blood Groups in Man.

"Here we cannot resist noting the not very practical finding by [Patricia] Tippett and [Phyllis] Teesdale of an anti-B-like agglutinin in the plasma of one of two, untinned, coelacanths they tested."

Ah, those were the days of real serology!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!

:D:D:D:D

Ok--I'll try to answer Fluffy's question: the tribe is the Jarawas?

http://en.wikipedia.org/wiki/Duffy_antigen_system

Lisa - Wow! Good job! I'm impressed!!

Also, I had no idea that Wikipedia had such detailed technical information on our Blood Bank topics. (Malcolm, did you write the article in Wikipedia???)

Lisa - Wow! Good job! I'm impressed!!

Also, I had no idea that Wikipedia had such detailed technical information on our Blood Bank topics. (Malcolm, did you write the article in Wikipedia???)

Nuffin to do wiv me Guv!!!!!!!!!!!!!!!!!!!

:):)

Stab in the dark here... primates?

Yes!

I think this is where I found that: http://en.wikipedia.org/wiki/ABO_blood_group_system

Yes!

I think this is where I found that: http://en.wikipedia.org/wiki/ABO_blood_group_system

From phylogenetic analysis, it is thought that A1 is the "original" human blood group (which makes me an original human, by the way) appearing some 4.5 to 6 million years ago. The wild type A genotype is termed as A101.

However, all gorillas are group B, whilst chimpanzees leck the B gene, but have at least two different O alleles.

Rabbits and guinea-pigs also express a B-like antigen on their red cells (which is why anti-B is adsorbed out RESt - rabbit erythrocyte stroma).

Pigs can have an A-like antigen, but interestingly, this only reacts with IgG anti-A, and not IgM anti-A, and this function of the pig's red cells was, once upon a time, used to try to predict the severity of haemolytic disease of the newborn due to anti-A. You can tell how effective this prediction turned out to be by the oh so common use of this technique today (:sarcasm::sarcasm:).

Right, come on then Deny, we need a question!!!!!!!!!!!!!!!!

:):)

From phylogenetic analysis, it is thought that A1 is the "original" human blood group (which makes me an original human, by the way)

Wow, me too! Now we have some great party conversation. "Who here is an original human?"

Wow, me too! Now we have some great party conversation. "Who here is an original human?"

Oooh! Oooh! Me, me me! *raises hand* I'm human, too!

So given that we're all humans here and not primates, even though both species exhibit ABO groups in their blood, that leads to the next question for this thread: After watching the following video:

http://www.youtube.com/watch?v=WnqVbcEb8AU

Are we as humans, any more closely related to primates other than blood groups??

:D:D (Come on now, the answer isn't that hard!! LOL)

Edited July 3, 201015 yr by LisaM

If this is accurate, there's 21 and the year is 1955--that's where I got the info:

http://en.wikipedia.org/wiki/Diego_antigen_system

I hate to say this, but there are now 22!!!!!!!!!!!!!!!!!!!!!!!!!!!

Poole J, Thornton NM, Tilley L, Lambert M, Mulvany L, Daniels G. Novel high incidence antigen in the Diego Blood Group System (DISK) and clinical significance of anti-DISK. Vox Sanguinis 2010; 99 (Suppl. 1): 54-55 (Abstract 4D-S30-03) and there is now another high incidence antigen within the Kell Blood Group System (Karamatic Crew V, Poole J, Watson T, Bullock T, Burton N, Daniels G. KASH (KEL34): A novel high incidence antigen in the Kell Blood Group System. Vox Sanguinis 2010; 99 (Suppl. 1): 357 (Abstract P-0722).

:eek::eek: