hi can anyone help me out with a blood bank problem. i am looking at a TENCELL ab screen. immediate spin all negative, Alb37 all negative, IAT all 2+ except donor R0. cell R0 has additional antigen U- and another R0 has U var. does anyone know what antibody gives these results in a screen? all responds are appreciated!

? anti-Fy3 ?

Since the negative cell is U negative, I would go there first (the U var cell expresses some U antigen). You will need to find two other examples of U negative cells to "rule-in" and confirm the specificity.

If U is not the answer, then I would look at those high-incidence antigens where antigen-negative status is seen more commonly in African populations. I would suspect Malcom's suggestion of anti-Fy3 if the negative donor cell is also Fy(a-b-). Your Ro U-negative cell is most likely from a donor of African descent. You can refer to the Blood Group Antigens section of this website, the 901 series: http://www.bloodbanktalk.com/bgs/list.cfm?sys=37; and browse through the antigen groups to determine what to investigate next.