currently in our SOP if we have a positive auto control and no other cells positve on the panel and a negative DAT we result it as AUTO ANTIBODY, however we have a new doctor at our facility who wants us to call it AUTO AGGLUTINATION. is our SOP INCORRECT or how would you report these resuts?

If you have a negative DAT? We don't call anything like that at all. Interesting....

currently in our SOP if we have a positive auto control and no other cells positve on the panel and a negative DAT we result it as AUTO ANTIBODY, however we have a new doctor at our facility who wants us to call it AUTO AGGLUTINATION. is our SOP INCORRECT or how would you report these resuts?

I don't think that your SOP is incorrect.

How can auto-agglutination come about unless there is an auto-antibody present to cause the auto-agglutination?

It would be a matter of semantics, but for the fact that they actually mean the same thing in the long run!

Possibly a case of the new doctor wanting to make his or her mark, and choosing the wrong subject?

Auto-agglutination is the demonstration of an auto-antibody, whether the DAT is positive or negative (and probably would be positive, if you were able to use monospecific anti-IgM, anti-IgA, etc.

:(

Very well-worded, Malcolm!

unless antibody screen is positve and our reference lab would ask if we did auto control

I second Malcolm's entire statement!!!

But .... could it be drug or disease instead of an acutal auto antibody??

Drugs and diseases can cause auto antibodies to manifest temporarily.

We would not run into the situation described because we do not do an autocontrol unless we have a positive screen. Then we do it with the panel. We don't run one routinely. Unless you are saying your screen is positive and your panel is negative, in which case we might repeat the screen to make sure there was not an error or contamination before we would call it an auto antibody. It is rather strange to have the screen completely positive (at some strength) and the panel completely negative except the auto control.

But .... could it be drug or disease instead of an acutal auto antibody??

MOST CERTAINLY Particular drugs are a HUGE cause of positive DAT's. :mad:

MOST CERTAINLY Particular drugs are a HUGE cause of positive DAT's. :mad:

But the original post stated that the patient's Direct Antiglobulin Test was negative, so I doubt that drugs had anything to do with the testing results.

But the original post stated that the patient's Direct Antiglobulin Test was negative, so I doubt that drugs had anything to do with the testing results.

Sorry, guess I kind of got of course....

I have encountered this before...transfusing AHG compatible blood seems to work just fine. You are probably right....but keep in mind that Auto's never "read the rule book".

Okay Malcolm, I am waiting for you to blast me for this last statement......:D:D:D:D:D:D:D:D:D:D

Sorry, guess I kind of got of course....

I have encountered this before...transfusing AHG compatible blood seems to work just fine. You are probably right....but keep in mind that Auto's never "read the rule book".

Okay Malcolm, I am waiting for you to blast me for this last statement......:D:D:D:D:D:D:D:D:D:D

Far from it; you are absolutely correct in this statement.

I wish they would; it would make life far simpler!

:)

Maybe the term Auto-agglutination causes less anxiety for nurses and physicians when considering potential tranfusion complications for patients in need.

anyone.. who can tell me what is the meaning of cold auto antibody?

anyone.. who can tell me what is the meaning of cold auto antibody?

Are you asking what the clinical significance is of a patient who has a cold Auto, or what it means in general?

currently in our SOP if we have a positive auto control and no other cells positve on the panel and a negative DAT we result it as AUTO ANTIBODY, however we have a new doctor at our facility who wants us to call it AUTO AGGLUTINATION. is our SOP INCORRECT or how would you report these resuts?

Not sure why you would want to run an Autocontrol if your Antibody Screen is negative; you could save yourself a big headache by discontinuing that practice. I did work somewhere many years ago that routinely ran an autocontrol with every antibody screen but we got tired of negative eluates and/or things we did not care about for transfusion purposes. MD could always order a DAT if they had hemolysis concerns. Just a thought...

Brenda Hutson, CLS(ASCP)SBB