Hello!

this is my doubt. We are using Axsym for blood donor screening, and we have some anti core (total) positives (low value). after that, we rescreen the blood sample in architect, and it give us a negative value.

does someone have any experience like that at your services??

does someone have any scientific (really scientific) explanation ????

thanks!

I have seen this phenomenon many times, even when repeating HBcAb with the same test system (we would repeat +s in duplicate). There was never any really satisfactory reason for this. The only thing we could comprehend is that the test is made extra sensitive for donor screening so that the slightest bit of carryover, incomplete washing, etc would lead to those weak + reactions. Even one of my own donations had such an event. Not much help but at least you know you are not alone.