In addition to giving antigen negative, Hemoglobin S negative blood to sickle cell patients, do you also perform coombs crossmatches when no alloantibodies are detected?

We only perform IS crossmatches when the Antibody Screen is negative.

we perform the complete cross match as per protocol.

best wishes.

We give RH & Kell phenotypically match and IS crossmatch compatible units if antibody screen is negative and no history of no antibody.

We give Rh & Kell phenotype matching & electronic crossmatch. We do not test for Hemoglobin S negative...

Our goal in our huge sicke cell population is to prevent alloimmunization. We try to match Rh, Kell, and Duffy in our population. We ask our Hem/Onc guys to let us know when we have a new sickle cell patient, and we tag them in the computer with our protocol. We give blood that is sicke cell screen negative in all sicke cell patient cases. We use electronic crossmatching unless they have a positive screen or a history of one.

BC

We match Rh and K for all routine transfusions to a sickle cell patient to prevent possible immunization.

WE only give HbS neg units for a red cell exchange.

We also try and get a compete phenotype on a pre-transfusion sample if possible, or use hypotonic wash and do it that way.

I'm just wondering why rcurrie would give blood that is Duffy matched? When you consider that it is likely that about 68% of your sickle population will group as Fy(a-b-), but the vast majority of these will have an FYB gene (granted, not expressed on the red cells), it would seem a bit of a waste of Fy(a-b-) blood when this may be required, sometimes in large amounts, for a sickle cell patient with a genuine FY/FY genotype and anti-Fy3.

It could be, of course, something as simple as that you have more Fy(a-b-) donors than we do in Britain, and that blood is more available to you.

It is not easy to find Fy(a-b-) donors in US. When you ask fro Fy(a-b-), one kid antibody & S or s...it becomes rare blood. Many times we need to import from other region or contact rare donor registry.

It is not easy to find Fy(a-b-) donors in US. When you ask for Fy(a-b-), one kid antibody & S or s...it becomes rare blood. Many times we need to import from other region or contact rare donor registry.