Recently we encountered a patient who is C+ and patient has clear cut anti-C in plasma , AC negative & DAT negative. no transfusion as per info from the patient. ANy idea , waht is going on here?

Recently we encountered a patient who is C+ and patient has clear cut anti-C in plasma , AC negative & DAT negative. no transfusion as per info from the patient. ANy idea , waht is going on here?

Any possibility this might be anti-Ce? This would react not react with the patient's own cells if his genotype was DCE/dce.

Did the patient get any sort of immunoglobulin that might have contained anti-C or any donor unit that might have?

it might also be some sort of DAT neg auto antibody. You might want to try autoadsorption just to see if it might work.

Alloanti-C in C-positive people have been reported several times in the literature. Check the Antigen Facts book of Reid and Lomas-Francis. If the person is Black, then their red cells could be C+weak and VS+, and this is the type of situation that most often occurs when there is alloanti-C in C positive people. Is the person Black? marilynm

I forgot to ask if the patient is female and has a history of any pregnancies? We had a White pregnant female who had alloanti-C in her serum, was C-positive. There have also been examples of naturally occurring anti-C. marilynm

Sorry I can not get all the information as I am home with my Son. I will try to get the info next week.