Are any countries using refrigerated platelets, Does anyone know of current research?

I'm just curious, what makes you ask this?  Did someone inadvertently put some platelets in a refrigerator?  

No, I have someone on staff that was doing research on Cryopreserved platelets and I was wondering on the history of it.

 

I'm looking forward to hearing what you discover.

Cold-stored platelets are being used in limited situations in the US. To my knowledge, they can only be used for active bleeding, which FDA has loosely defined. Most hospitals are not yet using them because of this loose definition of "active bleeding" and reimbursement. Here are some articles:

https://www.fda.gov/media/132379/download

https://mrdc.amedd.army.mil/index.cfm/media/articles/2015/FDA_approves_cold-stored_platelets_for_resuscitation#:~:text=The agreement by the FDA,33.8 to 42.8 degrees Fahrenheit.

 

No data on clinical outcomes being equivalent or better yet, so most are not implementing because maintaining two inventories is going to be a big ask. Awaiting clinical data.  Randomized trial in cardiac surgery being planned in USA.

Decades ago that's how we used to store plts.  Good for 3 days at that time.  My understanding of such is that refrigerated plts are able to function upon transfusion whereas the current room temp plts require an "adjustment" period before they are clinically functional.   I'd like to hear the current feelings on such (just so I'm not laboring under a delusion).

There are no clinical trial data of any use yet.  All the conclusions to date are based upon in vitro (laboratory) testing which has never been shown to correlate with clinical outcomes (stopping bleeding, thrombosis, etc.).  

Check for work done by Mayo Clinic. I believe that they are sending out cold platelets w/ red cells on trauma flights. Maybe someone here can provide a reference for their trauma studies.

I think Texas is studying this.  I have heard that the cold-stored platelets are already activated so are thought to work well for rapidly bleeding patients.  I don't think activated platelets last well in your average oncology patient.