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COVID and auto antibodies

BBfuntimes
in Transfusion Services

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comment_82761

In the recent months we have seen an increase in positive immediate spin crossmatches (grainy to 1+ reactions).  Antibody screens are negative in gel.  I am wondering if others are seeing this and if it is perhaps a COVID thing.  

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  • Arno
    Arno

    Not that I am aware of.  There are publications reporting an increase of DAT positive samples amongst Covid-19 patients. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414594/ According to th

  • AMcCord
    AMcCord

    We don't tend to do much Blood Bank testing for Covid patients now, however when we were doing types to give convalescent plasma we did see a few funky reactions in backtypes. Nothing strong. Whether

  • MAGNUM
    MAGNUM

    We use Capture, and we as well have seen an increased number of weak reaction at immediate spin.

comment_82765

Not that I am aware of. 

There are publications reporting an increase of DAT positive samples amongst Covid-19 patients. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414594/

According to the authors, the eluate (IgG) reacts only with cells from Covid patients and this state is likely to be transient (related to hyperinflammation in these patients).    

 

    comment_82772

    We don't tend to do much Blood Bank testing for Covid patients now, however when we were doing types to give convalescent plasma we did see a few funky reactions in backtypes. Nothing strong. Whether they were Covid related or just that patient...who knows. 

    comment_82778

    We use Capture, and we as well have seen an increased number of weak reaction at immediate spin.

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