Male boy of age 10 months, known case of Beta Thalassemia major, developed antibodies and not maintaining the Hemoglobin despite regular tansfusion i.e 2/ weeks. Patient Blood Group is Forward: A 3+, B3+, D4+ Reverse: anti A 2+, anti B 2+ Auto Weak+ 37: Forward: A0, B4+, D4+, Reverse anti A 4+, anti B0, Auto 0. E 0, C+, c+,e+ k+-, Jk+- All blood is incompatable, only least incompataible blood is available, but hemoglobin droped in one week by 2 to 3 grams, LDH increased. Can any boby give suggestion Dr. tariq