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One sample received different results from different Anti-D reagent: Ortho: Neg (IgM Anti-D,Colum Column agglutination technology ) DIAMED: POS 4+(IgM Anti-D,Colum Column agglutination technology ) IMMUCOR:POS 4+(IgG Anti-D,IAT AHG) Any ideas about this case？ THANKS -
Thanks! My further question about it is that, in this situation, can i issue the grouping result only based on forward grouping result? any supporting file for doing this?
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Reverse grouping is not required in infancts less than 6 months of age.But, i found many ABO discrepancies case in infacts between 6 months and 12 months of age. How do i handle this situations? Forrest
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we routinely transfuse packed cells
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In many Chinese hospitals, blood units are fully crossmatched due to following reasons:one is that hospital blood banks do not have the manpower and resources to perform complete antibody investigation, another is that the blood center do not perform the antibody screening for donor unit, and the hospital do not test it either since who can not chage the testing fee from donor.In this situation, we have to perform both major and minor XM. There is no problem to do so with conventional tube ITA, but the problems present when new technology introduced.The microcolumn technology is more sensitive than tube one,the recipient'DAT positive will result in minor XM's positive. however, the DAT is not the routine tesing for recipient.
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In China, we do not carry out the policy of T&S at blood transfusion department.we perform both major and minor crossmatch as a pre-transfusion tests,and we do not perform the antibody screening test for donor units. But, we have problems when we change Tube to microcolumn agglutination method. There is the highly frequent weak positive result of minor cross match with cassettes. We found the same situation from literatures issued by domestic magazine. The article reports that the positive rate of minor crossmatch is about 10~20% when application of microcolumn , the reason of high positive rate mainly due to Sensitized patient red blood cells, the result of DAT is weak positive. However, the positive results of Tube are very rare. The questions of minor crossmatch always trouble us, how do we handle this issue? Can we issue the blood unit with weak positive of minor crossmatch ( DAT positive)? Thanks in advance