Currently my facility is using PEG for screens and antibody ID. We want to go to LISS. We are finishing up our validation study and of course the LISS is not as sensitive as PEG. Our Medical Director was not happy with the % of sensitivity and specificity that I was using. I must admit I used the % that was used for another similar study. Here is my question, am I barking up the wrong tree looking at the % of sensitivity and specificity? I already know LISS will be lower than PEG. Should I be looking at the Predictive Values and Efficiency of the test rather than comparing the two out right? I am so frustrated at this point any and all help would be greatly appreciated. I am ready to switch my reagents I just need to get this issue solved.