Hi Patricia, We've been issuing electronically for 5 years (around 16K red cells pa, 80 something % issued electronically) - during that time we've had 2 reactions, which were weakly positive by manual gel (DiaMed). 1 in 2006, 1 last year - neither of which RCI could give a specificity for (which is a shame, as you could do some clever maths to work out the risk). The MHRA still haven't posted their guidance, but I have attached a copy of it (assuming my low tech skills can manage that) hth Stephen MHRA Guidance on Electronic Issue.pdf