Rashmi I agree that the analysers giving the negative results should be taken out of use immediately. I would suggest that discussions with the scheme organisers would be a constructive way forward. All methodologies used within the laboratory should be used for testing any external QC material and, particularly where there are discrepant results, all results should be submitted. I suspect that most labs. will not participate in a separate scheme for each analyser or method and most external QC schemes will not have the facility to allow the recording of the scenario that you have outlined. At least we have moved away from the days when any external QC sample was tested to death to get the 'right' answer! John