Pan-reactive

That sounds interesting and very similar! We're thinking to run the Bio-Rad variant D kit as it may just be a variant and just showing as D- in the cards which happens occasionally. Still a bit strange for any kind of anti-D to show reactions like this. I'll do the same as you did and have a chat with IBGRL about our findings to see if it's of any interest to them.

Not that we can tell, just an untransfused pre op patient.

I should also add that she is D negative!

So we've have an elderly lady's sample sent to our reference lab with ?Anti-D but when tested against 2 of our panels it's 3+ in the IAT cells and negative in Enzyme IAT. It was my understanding that the D antigen was entirely resistant to papain treatment. Are some epitopes cleaved off during the process which could be causing these reactions?