Winnie

Malcolm, thanks for your feedback- my sentiment exactly, I don’t see the point of restricting transfusion with only Group O red cells- it seem unnecessary. Some laboratories here in Oz are too cautious, our standards/guidelines mention exactly what you’ve stated, unless there is an allo-anti-A1 active at 37, the requirement is IAT compatible crossmatch (so A2 transfusions would suffice). Interesting to hear about your experience with loss of A or B antigen and AML! I’ve only seen cases with AML as well , not ALL. Publications also only mention myeloid leukaemias. You’ve inspired me to follow through with another patient of ours and their progress. 🙂

Hello everyone, new to this forum. I work in hospital pathology lab in Australia- would love some advice on whether it’s necessary to transfuse only Group O red cells to patient’s that are probable A3 subgroup? I understand there is a small risk of A3 subgroups developing an allo-anti-A1, if transfused A1 red cells, but if their reverse group shows an absence of reactivity to A1 cells, is it necessary to restrict transfusion to only Group O? Has anyone also seen cases of loss of ABO antigen in Acute Lymphoblastic Leukaemia which can render false A1 negative subtype? Our patient’s forward group has mixed field reactions to 3 different monoclonal Anti-A anti sera. Reverse group matches Group A. Cheers!

Thanks all! Hello from Down Under! Looking forward to learning and connecting with everybody across the world.