Bet'naSBB

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We might be the "Odd-Man-Out" - but, if the mom has an antibody and the DAT is negative on the cord sample, we don't test the plasma. If they order a neonate type and screen and the screen is negative, we don't give antigen negative units.............🙀................unless there is clinical evidence of hemolysis our Med Dir says it's warranted.

My question would be - how strong was the pre-transfusion reactivity? If it was only 1-2+ in SP / and the patient isn't a "larger" person, I personally would suspect that the antibody titer was diluted to such a degree that SP did not pick it up anymore....... (but I REALLY don't like SP.....it's just too wishy-washy.....JMHO)

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Not sure that there is a specific number. We just validated some Grifols antisera and ran 20 comparisons.

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At our facility, we have to do a cold adsorption IF the cold auto interferes with the reverse and/or ISXM. Since testing with "neat" plasma is our standard of practice, we would still report the XM as incompatible and send it out with a release stating the incompatibility was due to an autoantibody. We are not "allowed" to prewarm away IS reactions. 🥶 IF we prewarm - it's only if the cold has a high thermal amplitude and causes interference after 37deg incubation / antiglobulin phase...........but that's just us.........

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