Arno

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Hats off to Nicole and the whole IBGRL team

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Hello everyone, I have got the following questions a couple of times I was not able to answer, so I try my luck: would someone know why ficin is more often used in the US while papain is more commonly used outside the US? Both do have similar mode of actions, but I cannot figure out this geographical difference. European manufacturers mostly provide papain treated cells whereas US manufacturers ficin treated cells as far as I know (I might not be 100% right though). Had it to do with sourcing? User expectations? Practices (I believe the AABB technical manual refers to either ficin or papain..)? Thank you for the assist 😊

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2024-08935.pdf (federalregister.gov) I have not read it all but some BB tests seem to be out of scope such as the use of rare antisera/red blood cells when no reagent is commercially available as well adsorption techniques, Donath Landsteiner test, Drug Induced hemolysis tests and the Monocyte Monolayer Assay... not an exhaustive list but I might have missed while going though quickly these 500+ pages.

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Hello Malcolm, I hope you are doing good. I found this paper published in Blood in November 2023. The Cs a and Cs b Red Cell Antigens of the Cost Blood Group Collection Correspond to the HNA-3a and HNA-3b Neutrophil Antigens: Unexpected Twins with Implications for Sickle Cell Anemia - ScienceDirect

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