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I just answered this question. My Score PASS

I just answered this question. My Score PASS

I just answered this question. My Score PASS

I just answered this question. My Score PASS

I just answered this question. My Score PASS

I just answered this question. My Score PASS

I just answered this question. My Score PASS

I just answered this question. My Score PASS

I had hoped that the validation mania had subsided. It's good to see that there is still some common sense out there. I never did understand why so many of us felt the need to continually reinvent the square wheel when all the work on the round one had already been completed.

Awesome details. Thanks for all the information. I worked at couple of facilities that switched to 5 day plasma and I do not remember them doing any factor studies. They did a lots of validation with the ISBT labels. I do not remember the exact details. My supervisor said that since it has been approved by FDA, we do not need to repeat the factor studies but, has to make sure that the thawed labels match the product code for the frozen product. Is that right ?

**REVISED** 08/21/2017 TRM.41350 Compatibility Label/Tag Phase II A compatibilityBefore issuance, a label or tag including the following information is securely attached to each blood or component unit before issuance, and it remains attached until completion of the transfusion.: ● NOTE: A label or tag must be securely attached to every unit before issuance and remain attached untilIdentification of the transfusion is completed. The label must include appropriaterecipient with two patient and donor identifiers ● Blood (or component) unit identifier ● Recipient and donor blood groups, andtypes ● Interpretation of crossmatch testing interpretations.tests, where applicable ● Donor unit expiration date and time (as applicable) ● Special transfusion requirements (if warranted)

I agree with Malcolm. In theory, there may be examples of anti-K that only react with K+k- cells, but in practice it's a very rare event. One of my former colleagues/mentors once said that one shouldn't worry about missing a weak antibody. If the patient were unfortunate to be transfused antigen-positive blood, the former weak antibody would be super-strong next time around !!! Problem solved.

In my lab we follow the ANZSBT guidelines as shown below http://www.anzsbt.org.au/publications/documents/PLP_Guidelines_Mar07.pdf 2.1.3.5 The specificity of an antibody [including each individual antibody in multiple antibody mixtures] can normally be assigned when it is reactive with at least two reagent red cells carrying the corresponding antigen and non-reactive with two reagent red cells lacking the antigen. 2.1.3.6 The presence of anti-Jka, anti-Jkb, anti-S, anti-s, anti-Fya and anti-Fyb should be excluded using red cells with double-dose expression of the corresponding antigens.

Brain power? Bang goes any chance that I could do it then!!!!!!!!!! :o:o