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ABO diacrepancy


MyHerpesItch

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A 40 yo male w polycythemia vera patient was previously typed AB Pos antibody screen negative. He started taking Hydroxyurea to lower his RBC count. A month later his forward typing reaction was:

anti-A = 0

anti-B = mf

anti-D = 4+

control = 0

He has never has any transfusion. My question is how is, what's causing his ABO discrepancy? 

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Sorry. Reverse is his historical AB Pos.

a1 cells = 0

b cells = 0

Also I was reading on the polycythemia vera drug - Hydroxyurea, and it stated that an increase in Hgb F happens when taking it. But if I'm not mistaken, the change in normal Hgb A to Hgb F shouldn't change the RBC surface Ag expression.

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1 hour ago, MyHerpesItch said:

Sorry. Reverse is his historical AB Pos.

a1 cells = 0

b cells = 0

Also I was reading on the polycythemia vera drug - Hydroxyurea, and it stated that an increase in Hgb F happens when taking it. But if I'm not mistaken, the change in normal Hgb A to Hgb F shouldn't change the RBC surface Ag expression.

The change in the level of HbF, in itself, shows haematopoietic stress, and haemopoietic stress can lead to weakened expression of ABO antigens.

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