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Possible HLA on Ortho screen cell 2 on lot VS155-please report


Mabel Adams

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Is anyone else having problems with screen cell 2 on Ortho 0.8% screening cells lot VS155 being positive about 1+ with quite a few patients?  Then when panel A VRA313 is run, it almost looks like an anti-Leb but cells 6, 9 & 10 that it reacts with are all HLA pos and we can rule out anti-Le b with a panel B cell.  Of our seven patients, at least 2 have also reacted with cell 2 on the panel which makes me think panel cell 2 is also HLA pos, just not labeled as such. If you are seeing this, can you please report it to Ortho so they don't ever use this donor for a screen cell again?  All of the usual specificities are ruled out in these cases.  Most of the reactive samples are prenatals.

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