SMILLER Posted November 14, 2018 Share Posted November 14, 2018 Is there a difference clinically between a patient with anti-H vs anti-H1? The reason I ask is we have a patient who came in with an old Red Cross card from 1989. There is a copy of a report attached that has "Duffya" and "H1" (or maybe "Hi") on it. The patient has a negative antibody screen. Thanks, Scott Link to comment Share on other sites More sharing options...
Malcolm Needs ☆ Posted November 14, 2018 Share Posted November 14, 2018 No, but the old Red Cross card, or the person who typed it should I say, should be totally ashamed of their poor knowledge of nomenclature. Link to comment Share on other sites More sharing options...
Mabel Adams Posted November 14, 2018 Share Posted November 14, 2018 Could that be IH or HI? Link to comment Share on other sites More sharing options...
galvania Posted November 15, 2018 Share Posted November 15, 2018 HI sounds more like it. Link to comment Share on other sites More sharing options...
SMILLER Posted November 16, 2018 Author Share Posted November 16, 2018 OK, so what is HI then? (besides being insignificant for this patient) Scott Link to comment Share on other sites More sharing options...
Malcolm Needs ☆ Posted November 16, 2018 Share Posted November 16, 2018 Well, ANTI-HI is an antibody that is almost always an auto-antibody. It is an antibody that will react with almost everyone's red cells, including the patient's own, because it reacts against a combination of the H antigen and the I antigen, in a similar way to anti-ALeb reacting with group A red cells that are also Le(b+), anti-BLeb reacting with group B red cells that are also Le(b+) and anti-LebH reacting preferentially with group O red cells that are Le(b+). Anti-HI will react more strongly with group O "adult" red cells, than A, B or AB "adult" red cells, as group O red cells express more of the H antigen than do A, B or AB red cells (although the A, B and AB red cells will express at least some H antigen), but will NOT react with Oh "adult" red cells (or Oh "cord" or "neonatal" red cells, which are, essentially. I Negative), or red cells of any ABO type that are of the "Adult ii" type. As an Oh individual, who is also has the "Adult ii" type, anti-HI is never an allo-antibody. SMILLER and Ensis01 2 Link to comment Share on other sites More sharing options...
Mabel Adams Posted November 16, 2018 Share Posted November 16, 2018 If your patient doesn't type as O, then the old card can't mean anti-H. And a Bombay patient wouldn't lose their anti-H and have a negative screen now either, I don't think. Anti-HI (sometimes written IH) could likely have been identified back in the 80's when some places still did more room temperature testing. Anti-HI might have interfered then but with a negative screen you needn't worry about it now. The anti-Fya needs to be honored, of course. Ensis01 and SMILLER 2 Link to comment Share on other sites More sharing options...
SMILLER Posted November 17, 2018 Author Share Posted November 17, 2018 Thanks for your responses. It never occurred to me that the "HI" meant some type of compound antibody--I have never heard of one for H+I, but that is probably what was meant on the old Redcross card. At the time their reference Lab may have had some interference from it if they were looking at IS screen results back in the last century. The patient is A Pos, I suppose they were thinking it was a cold auto-antibody. They no longer have the records. (We were never too worried about her current typings "missing something".) Scott Link to comment Share on other sites More sharing options...
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