BES Posted October 15, 2018 Share Posted October 15, 2018 transfusion Link to comment Share on other sites More sharing options...
BES Posted October 15, 2018 Author Share Posted October 15, 2018 (edited) What is your policy for transfusion after the treatment is completed and the antibody screen is negative, again. Sorry the treatment is Daratumumab. Edited October 15, 2018 by BES missing treatment Link to comment Share on other sites More sharing options...
Mabel Adams Posted October 17, 2018 Share Posted October 17, 2018 Once the interfering drug is gone, we would treat them like a usual patient with a negative antibody screen. One caveat is that our BBIS won't allow an EXM for any patient who has ever had a positive antibody screen reported. If we ever reported the initial screen as positive instead of the DTT-treated screen (negative, I hope) we would have to do future XMs by IS rather than EXM. If we knew the patient would go back on it, I suppose we might give K negative units but most that I have seen go off of it didn't go back on and, frankly, most expired within a few months. This experience is mostly from the early days when it was only approved as a last resort therapy so now less refractory patients are taking the drug and may have different outcomes. Link to comment Share on other sites More sharing options...
BES Posted October 26, 2018 Author Share Posted October 26, 2018 Quote Thanks, very helpful. Link to comment Share on other sites More sharing options...
TreeMoss Posted October 29, 2018 Share Posted October 29, 2018 We give antigen-matched units when the patient is on Darzelex so they hopefully wouldn't build any antibodies. Would you continue that when the screen was once again negative, or would you just select any compatible unit? Link to comment Share on other sites More sharing options...
Ensis01 Posted October 30, 2018 Share Posted October 30, 2018 3 hours ago, TreeMoss said: We give antigen-matched units when the patient is on Darzelex so they hopefully wouldn't build any antibodies. Would you continue that when the screen was once again negative, or would you just select any compatible unit? Any comparable unit. David Saikin 1 Link to comment Share on other sites More sharing options...
BES Posted October 30, 2018 Author Share Posted October 30, 2018 We give antigen matched blood during the treatment of Darzelex (Daratumumab) and after treatment Kell negative, if patient typed K negative. I totally agree with the policy of Mabel Adams thread to go back to e-match or IS units after treatment with a negative antibody screen. Link to comment Share on other sites More sharing options...
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