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daratumumab


BES

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What is your policy for transfusion after the treatment is completed and the antibody screen is negative, again. Sorry the treatment is Daratumumab.

Edited by BES
missing treatment
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Once the interfering drug is gone, we would treat them like a usual patient with a negative antibody screen.  One caveat is that our BBIS won't allow an EXM for any patient who has ever had a positive antibody screen reported.  If we ever reported the initial screen as positive instead of the DTT-treated screen (negative, I hope) we would have to do future XMs by IS rather than EXM.  If we knew the patient would go back on it, I suppose we might give K negative units but most that I have seen go off of it didn't go back on and, frankly, most expired within a few months.  This experience is mostly from the early days when it was only approved as a last resort therapy so now less refractory patients are taking the drug and may have different outcomes.

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  • 2 weeks later...

We give antigen matched blood during the treatment of Darzelex (Daratumumab) and after treatment Kell negative, if patient typed K negative. I totally agree with the policy of Mabel Adams thread to go back to e-match or IS units after treatment with a negative antibody screen.

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