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group O RBCs for non O neonates


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11 hours ago, sherif said:

Did you mean wash all O RBCs units for  non O blood group ?

I think washed out the plasma and freed K+ is safer to newborn, and it is not too expensive, just 20 yuan more than the packed cells. And if do the anti-A, B  titre in the packed cells is also time consuming and money consuming. Just my personal opinion.

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Because of the rare risk of a fatal hemolytic reaction, we only use washed group O red cells for our premature newborns.  For other newborns and readmits we use ABO identical unless there is detectable maternal anti-A and/or anti-B, in which case we again use washed group O's.  There is about 20-40 ml of residual plasma in almost all red cell units, more than enough to cause severe hemolysis in rare instances.  We should not ignore that risk for our own convenience/inventory management/etc. in my view.  We only transfuse unwashed group O red cells to patients of unknown ABO type in emergencies.

 

There is additional evidence that ABO non-identical transfusions of incompatible antibody or soluble antigen causes harm to patients, in addition to the rare risk of life-threatening hemolysis.  We have published a summary of this evidence.

 

Is It Time to Reconsider the Concepts of "Universal Donor" and "ABO Compatible" Transfusions?

Refaai MA, Cahill C, Masel D, Schmidt AE, Heal JM, Kirkley SA, Blumberg N.

Anesth Analg. 2018 Jun;126(6):2135-2138. doi: 10.1213/ANE.0000000000002600. 

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7 hours ago, Neil Blumberg said:

Because of the rare risk of a fatal hemolytic reaction, we only use washed group O red cells for our premature newborns.  For other newborns and readmits we use ABO identical unless there is detectable maternal anti-A and/or anti-B, in which case we again use washed group O's.  There is about 20-40 ml of residual plasma in almost all red cell units, more than enough to cause severe hemolysis in rare instances.  We should not ignore that risk for our own convenience/inventory management/etc. in my view.  We only transfuse unwashed group O red cells to patients of unknown ABO type in emergencies. 

 

There is additional evidence that ABO non-identical transfusions of incompatible antibody or soluble antigen causes harm to patients, in addition to the rare risk of life-threatening hemolysis.  We have published a summary of this evidence.

 

Is It Time to Reconsider the Concepts of "Universal Donor" and "ABO Compatible" Transfusions?

Refaai MA, Cahill C, Masel D, Schmidt AE, Heal JM, Kirkley SA, Blumberg N.

Anesth Analg. 2018 Jun;126(6):2135-2138. doi: 10.1213/ANE.0000000000002600. 

Thanks alot

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