Sherif Abd El Monem Posted September 10, 2018 Share Posted September 10, 2018 My question is "Can we do pretransfusion leukoreducetion at any time till expire date or must be within 72 hours from collection?" Link to comment Share on other sites More sharing options...
Joanne P. Scannell Posted September 11, 2018 Share Posted September 11, 2018 We haven't used "Post-Storage Leukoreduction" (aka Bedside Leukoreduction Filters) for many years. Search the literature and you will find that they are essentially useless. Leukoreduction is accomplished by adhesion, not size so effective reduction is dependent upon the activity of the leukocytes. Once they 'die' and breakdown during storage (a few days), they won't adhere to the filter no matter how old the unit is. In addition, the by-products of their breakdown, which cause reactions, are now released into the plasma and there are now leukocyte fragments floating in the plasma which could result in reactions caused by pulmonary filtration of these particulates or sensitization to their HLA Antigens. Bottom Line: Leukocyte reduction is effective when performed shortly after donation while the leukocytes are still viable and will adhere to the filter. Henrique, Ensis01 and Malcolm Needs 3 Link to comment Share on other sites More sharing options...
Sherif Abd El Monem Posted September 11, 2018 Author Share Posted September 11, 2018 32 minutes ago, JPSCANNELL f. CROKE said: We haven't used "Post-Storage Leukoreduction" (aka Bedside Leukoreduction Filters) for many years. Search the literature and you will find that they are essentially useless. Leukoreduction is accomplished by adhesion, not size so effective reduction is dependent upon the activity of the leukocytes. Once they 'die' and breakdown during storage (a few days), they won't adhere to the filter no matter how old the unit is. In addition, the by-products of their breakdown, which cause reactions, are now released into the plasma and there are now leukocyte fragments floating in the plasma which could result in reactions caused by pulmonary filtration of these particulates or sensitization to their HLA Antigens. Bottom Line: Leukocyte reduction is effective when performed shortly after donation while the leukocytes are still viable and will adhere to the filter. Thanks but leukoreduction after 72 hours from collection less effective or worthless ? Link to comment Share on other sites More sharing options...
Malcolm Needs ☆ Posted September 11, 2018 Share Posted September 11, 2018 Worthless. Joanne P. Scannell and Henrique 2 Link to comment Share on other sites More sharing options...
Sherif Abd El Monem Posted September 12, 2018 Author Share Posted September 12, 2018 22 hours ago, Malcolm Needs said: Worthless. Link to comment Share on other sites More sharing options...
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