Jump to content

Anti-Can?


Kayla Ace

Recommended Posts

I was wondering if anyone had any information regarding an Anti-Can? In Marion E. Reid & Christine Lomas-Francis's "Blood Group Antigens and Antibodies" guide, they reference an 'Anti-Can' which reacts like an Anti-M but mostly with Black donors vs Caucasians. However I am unable to find any more information regarding this antibody. Would greatly appreciate any input or any further reading materials that mention this antibody. Thanks!

Link to comment
Share on other sites

The Can antigen is now one of those included in the MN CHO Blood Group Collection (see Reid ME, Lomas-Francis C, Olsson ML.  The Blood Group Antigen FactsBook.  3rd edition, 2012, Academic Press).  These antigens/antibodies are NOT considered to be of clinical significance whatsoever, in terms of either transfusion reactions or HDFN, but It may be that GlnNAc-containing O-glycans confer a selective advantage against invasion by Plasmodium falciparum merozoites, which may explain why the antigen is found more frequently in Black individuals than White.

Link to comment
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now
  • Recently Browsing   0 members

    • No registered users viewing this page.
  • Advertisement

×
×
  • Create New...

Important Information

We have placed cookies on your device to help make this website better. You can adjust your cookie settings, otherwise we'll assume you're okay to continue.