Kayla Ace Posted August 22, 2018 Share Posted August 22, 2018 I was wondering if anyone had any information regarding an Anti-Can? In Marion E. Reid & Christine Lomas-Francis's "Blood Group Antigens and Antibodies" guide, they reference an 'Anti-Can' which reacts like an Anti-M but mostly with Black donors vs Caucasians. However I am unable to find any more information regarding this antibody. Would greatly appreciate any input or any further reading materials that mention this antibody. Thanks! illinoisbloodbanker 1 Link to comment Share on other sites More sharing options...
Malcolm Needs ☆ Posted August 22, 2018 Share Posted August 22, 2018 The Can antigen is now one of those included in the MN CHO Blood Group Collection (see Reid ME, Lomas-Francis C, Olsson ML. The Blood Group Antigen FactsBook. 3rd edition, 2012, Academic Press). These antigens/antibodies are NOT considered to be of clinical significance whatsoever, in terms of either transfusion reactions or HDFN, but It may be that GlnNAc-containing O-glycans confer a selective advantage against invasion by Plasmodium falciparum merozoites, which may explain why the antigen is found more frequently in Black individuals than White. AMcCord, AuntiS and galvania 3 Link to comment Share on other sites More sharing options...
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