Jump to content

Why ABO IgM antibodies persist for life


Recommended Posts

Hi all.

I acknowledge that most seniors on this platform are aware of this fact. However I thought to share it because I recently attended a 'Training' and this ? could not be answered. I recently read that it's because B-lymphocytes have some receptors that are able to interact with sugar-based antigens without the help of T-helper cells which can directly initiate B-cells production of IgM, and because of lack of the help of the T-helper cells, class switching does not occur. Memory cells are also NOT produced, so antibody production continues only as long as there is antigen exposure.
ABO antibodies are an example of T-independent immune response. The IgM antibodies are directed against the bacteria in the gut but cross-react with A & B antigens on RBCs.

This is especially for the attention of youngies like me. BUT I am expecting the input from the seniors here. Thank you and have a good day. 

Edited by Muhammad Awwal
Link to comment
Share on other sites

There are two books that I would recommend upon the subject.  The first is Avent ND, Fundamentals of Biomedical Science, Transfusion and Transplantation Science.  2nd Edition, Oxford University Press 2018 (ISBN: 978-0-19-873573-1), Chapter 1.  The second is Sompayrac L.  How The Immune System Works.  5th Edition, Wiley Blackwell 2012 (ISBN: 978-1-118-99777-2).

Link to comment
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now
  • Recently Browsing   0 members

    • No registered users viewing this page.
  • Advertisement

×
×
  • Create New...

Important Information

We have placed cookies on your device to help make this website better. You can adjust your cookie settings, otherwise we'll assume you're okay to continue.