Tabbie Posted July 21, 2018 Share Posted July 21, 2018 Hi All Lewis antibody exclusions. Realise they are rarely clinically significant only causing HTR and would perform crossmatch compatible. However I want to clarify the theory for exclusions. Human Anti-Lea is found in Le(a-b-) however exception to rule in Tawain where 10 Lea (a-b+) patients with anti-Lea were found. Most anti-Lea contains weak anti- Leb causing false positives. However monoclonal reagents seem to indicate no cross reactivity? What reagents do you use to exclude the presence of either anti-Lea or Leb ? Thanks Link to comment Share on other sites More sharing options...
galvania Posted July 23, 2018 Share Posted July 23, 2018 the same as you would for any other antibody But you need to make sure that if there is an anti-Lea or -Leb present that it is reacting strictly at 37°C. Otherwise no clinical relevance at all Malcolm Needs and Tabbie 1 1 Link to comment Share on other sites More sharing options...
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