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Positive Antibody Screen due to Rhig


richj

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You could do a selected cell panel.  Just make sure you cover all the antigens that are required in Canada.  Here it is DCEce Kk FyaFyb JkaJkb LeaLeb P1 and MNSs, I think.  Immucor has a 20 cell panel that has the upper ten cells are all D+, and the lower ten cells are D=.  Cells 11, 12, & 13 can be used to screen for antibodies other than anti-D.

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We check for a 3 month RHIG history (probably could be longer but we chose 3 months).  If the ABSC is + we do a mini panel (Ortho panel has cells marked with * - Immucor has cells with brackets;  if negative rule out significant antibodies other than D. We then call it Anti-D RHIG.  This Anti-D only requires a full AHG crossmatch while it is demonstrating.  If patient returns ABSC Neg we can go back to electronic XM.

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Thanks for the replies.

I thought maybe there was a new practice being adopted out there where you didn't have to rule out other antibodies, just confirm Anti-D in Moms having received Rhig. 

Heard rumblings in the greater Toronto area.

Thanks

Richard

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Here in the UK, not only do we perform an antibody ID but we also refer for quantification.  If the prophylaxis is detected in the 28 wk bloods then repeats are obtained as though the antibody were immune.  If it is detected for the first time after 28 wks then we refer for quantification but do no further testing if the antibody level is within the reference range for prophylaxis (unless detected immediately prior to delivery)

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