Amra23 Posted November 15, 2017 Share Posted November 15, 2017 Hi all. We have an 11 months old female pacient O Rh(D)negative Ccddeek- on forward group.Reverse group shows no antibodies in B cells and +3 with A1 cells.Controls negative.I performed a weak D test and after IAT faze I got a +3 result with anti-D(monoclonal).So I believe is a O Rh( D)weak type 1,right? Can we give her red blood cells D positive with no problem?Or we'd be much safer with D negative transfusion? Thank you. Link to comment Share on other sites More sharing options...
Malcolm Needs ☆ Posted November 15, 2017 Share Posted November 15, 2017 No! Sorry Amra23. You do probably have a baby with a Weak D Type 1, but you do not necessarily have a baby with a Weak D Type 1. Depending on what your monoclonal anti-D reagent(s) are designed to detect, you could, for example, have a baby with a Partial D VI, and the very last thing you want to do is give a female patient with such a partial D type, D Positive blood. Certainly, for the time being, I would cross-match D Negative blood until the D type has been proven (either using a whole lot of different anti-D reagents designed to detect various weak or partial D types, or at a molecular level). It may well be a Weak D Type 1, and so it could be argued that it is a waste of D Negative blood to give this to her, but, personally, I would be devastated if I gave a baby girl D Positive blood, before I had a definitive D type on her, only for her to make an allo-anti-D, which could have a terrible effect on her ability to produce children herself later in life. John C. Staley and BldBnker 2 Link to comment Share on other sites More sharing options...
Amra23 Posted November 16, 2017 Author Share Posted November 16, 2017 Thank you,Malcom, your answer was very enlightening for me! Have a great day! Link to comment Share on other sites More sharing options...
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