SMILLER Posted November 14, 2017 Share Posted November 14, 2017 (edited) Are we the only ones still screening units for patients producing anti-Lewis A? Is there ever a reason to do this for routine cross matches? Scott Edited November 14, 2017 by SMILLER oops! Link to comment Share on other sites More sharing options...
Malcolm Needs ☆ Posted November 14, 2017 Share Posted November 14, 2017 Probably! We haven't screened for the Lea antigen for anyone with an anti-Lea for years in the UK, and we haven't come across a transfusion reaction - although there are reports in the literature. SMILLER and StevenB 2 Link to comment Share on other sites More sharing options...
AuntiS Posted November 16, 2017 Share Posted November 16, 2017 We don't. We don't carry the antisera for testing. Also, in Canada, the national blood supplier no longer routinely tests for it. I suppose if someone had a hemolytic anti-Lea something could be done as a special case, but not routinely. SMILLER 1 Link to comment Share on other sites More sharing options...
Dansket Posted November 16, 2017 Share Posted November 16, 2017 If the current antibody screen is negative we issue electronically crossmatched units untested for Lea. If the current antibody screen is positive, we issue IgG-crossmatch compatible units untested for Lea mollyredone and dcubed 2 Link to comment Share on other sites More sharing options...
SMILLER Posted November 16, 2017 Author Share Posted November 16, 2017 Ja. Here, if the anti-Le a shows up on an inpatient, we set up 2 AHG crossmatched units, because that is what we do for all atypical antibody patients. But if it does not show up in the antibody screen, we have to order confirmed Le a units from our blood supplier and XM those! It's so 20th century... Scott Link to comment Share on other sites More sharing options...
Malcolm Needs ☆ Posted November 16, 2017 Share Posted November 16, 2017 1 hour ago, SMILLER said: Ja. Here, if the anti-Le a shows up on an inpatient, we set up 2 AHG crossmatched units, because that is what we do for all atypical antibody patients. But if it does not show up in the antibody screen, we have to order confirmed Le a units from our blood supplier and XM those! It's so 20th century... Scott Sorry Scott. In my personal opinion, and it is only my personal opinion, it's not 20th century........it is at best 18th century!!!!!!!! SMILLER and StevenB 2 Link to comment Share on other sites More sharing options...
Laurie Underwood Posted November 20, 2017 Share Posted November 20, 2017 If the patient has a history of Anti-Le(a) and the current antibody screen is negative we perform an IS/AHG crossmatch and do not antigen type the units. If the Anti-Le(a) is active then we will give antigen negative units. BldBnker 1 Link to comment Share on other sites More sharing options...
Malcolm Needs ☆ Posted November 21, 2017 Share Posted November 21, 2017 11 hours ago, Laurie Underwood said: If the patient has a history of Anti-Le(a) and the current antibody screen is negative we perform an IS/AHG crossmatch and do not antigen type the units. If the Anti-Le(a) is active then we will give antigen negative units. Given the number of reactions that are recorded in the literature, which are very few, and the fact that the small amount of plasma left on the red cells to be transfused will very readily inhibit in vivo the anti-Lea in the patients plasma, I think this is overkill. exlimey 1 Link to comment Share on other sites More sharing options...
SMILLER Posted November 21, 2017 Author Share Posted November 21, 2017 From you to our pathologist's ear, Malcolm! Scott BldBnker and AMcCord 2 Link to comment Share on other sites More sharing options...
galvania Posted November 21, 2017 Share Posted November 21, 2017 3 hours ago, Malcolm Needs said: I think this is overkill. Malcolm, are you really trying to kill Mr. Lewis?????????? NicolePCanada and SMILLER 1 1 Link to comment Share on other sites More sharing options...
Malcolm Needs ☆ Posted November 21, 2017 Share Posted November 21, 2017 No Anna. NicolePCanada 1 Link to comment Share on other sites More sharing options...
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