Fya-: Fyb,bweak (or) Fybweak,bweak

[JimmyBob]

Where a patient is Fya- and a genotyping kit is unable to resolve homo/heterozygosity with respect Fybweak, such that, it states "Fyb,bweak (or) Fybweak,bweak", should the phenotype be stated as Fya-,Fybweak or Fya-,Fyb+ or something else?

 

 

[MeganPLT]

This is not my area of expertise but did you ask the vendor for interpretation? I know the Duffy phenotype is based on few alleles, including the GATA box silencing mutation - so I would think there would be a couple factors to consider right? I would assume if the FyB allele is present, even if weak, you would want to call them FyB pos as a donor, but if it is a weak expression and as a recipient they could possibly make anti FyB you'd want that documented as well! I am curious if you come up with an answer... please let us know (looks like there were a lot of views for this string but no answers)! Sorry I can't be of more help!

[Malcolm Needs ☆]

I was wondering if, when you were talking about a weak Fy^b antigen, you were talking really weak, as in an Fy^x, or just a little weak, as in obviously Fy(b+), but weaker than normal.