NAN47 Posted August 17, 2016 Share Posted August 17, 2016 Hi , we have in the last couple of weeks had two cases of patients with anti-c , reacting with the A cells of the blood group, i have never saw this before ( only the usual cold reacting antibodies such as Anti-M etc) and was just wondering if this is something that others experience and why this is happening? The supplier has confirmed that the A cells are A neg (rr) cells. Thanks Tricia gagpinks 1 Link to comment Share on other sites More sharing options...
Malcolm Needs ☆ Posted August 17, 2016 Share Posted August 17, 2016 Hi Tricia, It isn't actually that uncommon a phenomenon, and is due to the anti-c being, at least partially, IgM in nature. exlimey, Auntie-D, David Saikin and 2 others 5 Link to comment Share on other sites More sharing options...
exlimey Posted August 17, 2016 Share Posted August 17, 2016 Most of the common Rh antibodies have been reported as IgM. A "saline-reactive" anti-E is probably the most often seen. I've personally seen an anti-e that appeared to be IgM. Way back when, in the dawn of time........there was serious concern over examples of IgM anti-D potentially causing ABO reverse typing discrepancies - hence why the commercial reverse calls are all Rh-. Malcolm Needs, gagpinks, David Saikin and 1 other 4 Link to comment Share on other sites More sharing options...
NAN47 Posted August 17, 2016 Author Share Posted August 17, 2016 Thanks for the responses Hi Malcolm, not sure if you remember but I spoke to you at Scotblood this year! tricia Malcolm Needs 1 Link to comment Share on other sites More sharing options...
Malcolm Needs ☆ Posted August 17, 2016 Share Posted August 17, 2016 2 hours ago, NAN47 said: Hi Malcolm, not sure if you remember but I spoke to you at Scotblood this year! I do indeed Tricia, and it was a real pleasure! NAN47 1 Link to comment Share on other sites More sharing options...
NAN47 Posted August 17, 2016 Author Share Posted August 17, 2016 likewise Malcolm, always nice to put a face to a name Malcolm Needs 1 Link to comment Share on other sites More sharing options...
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