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Anti-CD47

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Does anti-CD47 interfere with your antibody screen and compatibility testing like the anti-CD38? Does it affect patient's DAT?

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Unfortunately the answer is, it depends...  If the anti CD47 is a human antibody, then it will cause a positive DAT as CD47 is expressed on most cells in the body including erythrocytes.  If the anti CD47 is mouse or goat then it will not as this antibody will bind to CD47 but will not cause the same interference we see with Daratumamab.  I believe recent therapies involve blocking some of the CD47 receptors. 

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