WisKnow Posted August 12, 2016 Share Posted August 12, 2016 Does anti-CD47 interfere with your antibody screen and compatibility testing like the anti-CD38? Does it affect patient's DAT? Link to comment Share on other sites More sharing options...
noelrbrown Posted August 15, 2016 Share Posted August 15, 2016 Unfortunately the answer is, it depends... If the anti CD47 is a human antibody, then it will cause a positive DAT as CD47 is expressed on most cells in the body including erythrocytes. If the anti CD47 is mouse or goat then it will not as this antibody will bind to CD47 but will not cause the same interference we see with Daratumamab. I believe recent therapies involve blocking some of the CD47 receptors. AMcCord, mrpessimist, WisKnow and 2 others 5 Link to comment Share on other sites More sharing options...
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