Unexplained Anti-C

[gagpinks]

Hi Malcolm

 We have a case where 32 year old pregnant lady Oneg rr and her partner is R2r. Her antibody screen was negative  at 12 weeks, she has been given prophylactic anti-D at 19 weeks,  Now her antibody screen is Positive and look like she developed Anti-D(proph D) and Unexplained anti-C.

As far as we know this is her first pregnancy and no previous miscarriage or no transfusion history. How did she develop anti- C?Are Anti-D injection  pure anti-D or they can contain mixture of Rh antibody? Do you think anti-C could have come from Prophylactic anti-D injection.

[tbostock]

Hi Malcolm

 We have a case where 32 year old pregnant lady Oneg rr and her partner is R2r. Her antibody screen was negative  at 12 weeks, she has been given prophylactic anti-D at 19 weeks,  Now her antibody screen is Positive and look like she developed Anti-D(proph D) and Unexplained anti-C.

As far as we know this is her first pregnancy and no previous miscarriage or no transfusion history. How did she develop anti- C?Are Anti-D injection  pure anti-D or they can contain mixture of Rh antibody? Do you think anti-C could have come from Prophylactic anti-D injection.

Yes, we see passive transfer of Anti C every once in a while with Rhophylac.

[Dr. Pepper]

Once in a while we outdate a vial of Rhophylac so I dilute it a bit and give it to the students to do a panel. Panel always shows anti-D+C

[gagpinks]

Thanks everyone for replying,much appreciate! !

In this case do you think we should flag this patient for Anti-C?

Thanks everyone for replying,much appreciate! !

In this case do you think we should flag this patient for Anti-C?

Thanks everyone for replying,much appreciate! !

In this case do you think we should flag this patient for Anti-C?

[Auntie-D]

We send the sample for titres and again for a second time. If the titre is falling, we suggest that it is due to the Rhophylac, if rising, immune

[Malcolm Needs ☆]

Please see my reply to this post in the other question posed.