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titration studies


Alana

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NO!  The chances of a warm auto-antibody causing clinically significant HDFN are minute, and, in any case, what cells are you going to use?

 

The other thing is that how much of the maternal auto-antibody is going to be free in here plasma, how much is going to be extra-circulatory and how much is "stuck" to her own red cells?  How are you going to get an accurate answer?

 

If you are really worried about a maternal auto-antibody affecting the baby (and DON'T WORRY, unless the auto-antibody is exceptionally strong), then MCA Doppler/ultrasound is the way to go, rather than performing a titration that will tell you precisely nothing.

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Shortly before retiring my discussions with our Obstetric Consultants in our busy Maternity Department showed that whilst we agreed performing regular quantitations on maternal anti-D and anti-c antibodies was worthwhile I did manage to *almost* persuade them that titring other antibodies was  of virtually no assistance in management of the pregnancy compared to MCA Doppler/ultrasound.

We parted without a conclusion being reached.

Since I left the number of titrations has remained fairly constant but my garden is far better tended.

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