B Sub Group

[khalidm3]

A blood donor revealed no reaction in forward: Anti A= 0 Anti B=0, Anti AB=0 Anti D= 0 Control= 0 Reverse A cells= 4+ B cells= 0, O cells=0 (Room temperature and 4 C)

We performed adsorption elution by using plasma from Blood Group A donor. The elute produced 3+ reaction with B Cells and Control elute negative.

What to write donors blood group?

[Malcolm Needs ☆]

At first sight, as it were, it sounds like an (incredibly rare) case of Bel.

If the donor is Le(a-b+) (or Le(a-b-) and a Secretor) it might just be worthwhile seeing what he or she is secreting in his or her saliva. Bel's secrete H, but not B.

It might also be worthwhile having a sample looked at by someone like Prof. Martin Olsson in Lund, Sweden at a molecular level, in order to see if there are any nucleotide changes from either a normal O or a normal B.

[Rh-fan]

Most Bel samples have a form of anti B in the serum.

Also chimerisme is an option, and maybe (but also very rare) is the option of Bombay-like due to a very weak H antigen, but than also you can see a (auto) anti H in the serum.

[DPruden]

Obtain any clinical history of adenocarcinoma of pancreas, ovary, stomach, biliary (gall bladder, bile ducts, etc.). These tumors can produce large amounts of soluble A and B and can neutralize anti-A and anti-B reagents.

[khalidm3]

Obtain any clinical history of adenocarcinoma of pancreas, ovary, stomach, biliary (gall bladder, bile ducts, etc.). These tumors can produce large amounts of soluble A and B and can neutralize anti-A and anti-B reagents.

Thanks all, he is a healthy blood donor. No history of carcinoma

[mrhelton]

This would be an excellent specimen for molecular testing -- if you do send it for that, would you share the results of the findings?

Thanks

[Nisar]

Acc0rding t0 the basic principle if the d0n0r is resp0nding t0 envir0mental antigen A and n0t t0 B it means that there is m0st pr0bably B antigen present 0n d0n0r red cells thats y the the immune system is n0t repnding t0 envir0mental B antigen,s0 it is m0st pr0b sub gr0up 0f B,just after Ads elu tech perf0rm secret0r studies f secret0r :cries:and als0 check the cells f0r H antigen t0 reach t0 the c0nclusi0n

[Yanxia]

It looks like Bel (Bel will not have anti-B in the reverse type), and Para-bombay type. To differ it just use anti-H , be cautious parallel with 2 tube B cells and 2 tube 0 cells.