Donor Lymphocyte Infusion

[Liz]

Information and references on Donor Lymphocyte Infusion would be appreciated.

Thanks

[David Saikin]

I think that transfusing allogeneic lymphocytes would be dangerous.

Edited January 27, 2011 by David Saikin
grammar

[Liz]

Hello Dave

It is, we give it in the case of relapse post BMT to have GvL and ofcourse there will be GvH. So the balance is the tricky part. In AML the response is reportedly not good without chemo, I was wondering what dose per kg is being given.

[Liz]

This is a case of AML.

[CM2]

We dont do DLI's too often. Maybe 1 a year. A good candidate would have received an allo transplant from that same donor already but their bone marrow or peripheral chimerisms show increasingly mixed populations (% donor cells drops), or disease relapse AND they dont have significant problems with GVH yet. A small dose is given to start of around 1 x 10^7 cd3/kg and wait to see if they get good response without causing too much GVH. Good response = an increase in % donor cells without significant GVH complications. If the dr feels more is needed we try ascending doses of 5 x 10 ^7, then 1 x 10^8.

PS. Randomly giving cancer patients lymphocytes Would be dangerous (Thou shalt irradiate) if you hadnt already transplanted them with marrow cells from that same donor earlier, thus replacing their immune system =)

Edited February 8, 2011 by CM2
Adding PS

[Liz]

Thank you for the useful information

Cheers