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Cryopreserved whole cord blood


SBBDM

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Greetings,

I would be interested in knowing about protocols/challenges in the transfusion field using cryopreserved whole cord blood units (Autologous)

a) Are there accepted time limits?

B) Do some people use a thawing and/or transfer procedure

B) Are these units washed to remove debris of rbc, excess Hemoglobin, DMSO(units are 5% vol)?

c) Are units diluted (3X?) with Albumin/dextran

d) Can the units be infused unmanipulated? (To the extent that DMSO is tolerated by recipient)

Thank you in advance for any suggestions?

John

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  • 12 years later...

This is a very old topic and if @SBBDM or others need up-to-date information, I'd suggest contacting your relevant regulatory agency for this information as it can vary significantly based on the organization.  From the Cord Blood Association Fact Sheet (December 2001):

Cord Blood Banking Standards and Accreditation
Standards and voluntary accreditation programs for
cord blood banks are maintained by AABB and the
Foundation for the Accreditation of Cellular Therapy
(FACT). Health professionals and expectant parents
can look for these bank accreditations.

Regulation of Cord Blood Banks
Cord blood banking regulations vary widely among
countries that have regulations. In Australia, banks
have been regulated by the Australian Therapeutic
Goods Administration (TGA) since 2007. In the
European Union, regulations have been under the
European Directives for Tissues and Cells since 2004.
In the United States, the Food & Drug Administration
(FDA) issued a final guidance for licensure of
unrelated donor cord blood banks in 2011.

 

 

 

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