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Testing For Sickle Cell Patients


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  • 2 months later...
  • 2 weeks later...

Our goal in our huge sicke cell population is to prevent alloimmunization. We try to match Rh, Kell, and Duffy in our population. We ask our Hem/Onc guys to let us know when we have a new sickle cell patient, and we tag them in the computer with our protocol. We give blood that is sicke cell screen negative in all sicke cell patient cases. We use electronic crossmatching unless they have a positive screen or a history of one.

BC

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We match Rh and K for all routine transfusions to a sickle cell patient to prevent possible immunization.

WE only give HbS neg units for a red cell exchange.

We also try and get a compete phenotype on a pre-transfusion sample if possible, or use hypotonic wash and do it that way.

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  • 7 months later...

I'm just wondering why rcurrie would give blood that is Duffy matched? When you consider that it is likely that about 68% of your sickle population will group as Fy(a-b-), but the vast majority of these will have an FYB gene (granted, not expressed on the red cells), it would seem a bit of a waste of Fy(a-b-) blood when this may be required, sometimes in large amounts, for a sickle cell patient with a genuine FY/FY genotype and anti-Fy3.

It could be, of course, something as simple as that you have more Fy(a-b-) donors than we do in Britain, and that blood is more available to you.

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