johna Posted December 28, 2007 Share Posted December 28, 2007 First of all Happy New Year to everyone!As far as I know Ortho is the only company manufacturing an Anti-C3b product in the U.S. and they are also producing an Anti-C3b/C3d reagent. Was wondering if anyone has a preference between these two reagents and if so why? I believe there may be some price difference between the two which may be a consideration. Thanks! Link to comment Share on other sites More sharing options...
David Saikin Posted December 30, 2007 Share Posted December 30, 2007 If I recall my complement activity, doesn't C3b deteriorate into C3d in vivo? It seems that a reagent that detects both will provide more information than the alternate. Link to comment Share on other sites More sharing options...
donellda Posted December 30, 2007 Share Posted December 30, 2007 I thought that Immucor had an Anti-C3b antisera also. Link to comment Share on other sites More sharing options...
johna Posted December 31, 2007 Author Share Posted December 31, 2007 I thought that Immucor had an Anti-C3b antisera also. According to my product catalog they do not have an anti-C3b reagent. Link to comment Share on other sites More sharing options...
donellda Posted December 31, 2007 Share Posted December 31, 2007 I guess the Immucor product is antiC3b/C3d. It's a Gamma-clone product. Link to comment Share on other sites More sharing options...
Eagle Eye Posted January 1, 2008 Share Posted January 1, 2008 We use Immucor/Gamma product which is -C3b-C3d. Link to comment Share on other sites More sharing options...
KathleenSL Posted February 20, 2008 Share Posted February 20, 2008 I believe Ortho makes an Anti-C3d reagent and an Anti-C3b,-C3d reagent, but not an Anti-C3b reagent. A reagent that just contained anti-C3b would be of limited use (just IATs), it shouldn't be used as the sole reagent in DAT to detect complement (C3d and/ or C3b) on the patient's RBCs. Link to comment Share on other sites More sharing options...
johna Posted February 20, 2008 Author Share Posted February 20, 2008 I believe Ortho makes an Anti-C3d reagent and an Anti-C3b,-C3d reagent, but not an Anti-C3b reagent. A reagent that just contained anti-C3b would be of limited use (just IATs), it shouldn't be used as the sole reagent in DAT to detect complement (C3d and/ or C3b) on the patient's RBCs. Thanks for the correction Kathleen, my miscue. You are correct. I should have said that Ortho makes an anti-C3d (not anti-Cb). Link to comment Share on other sites More sharing options...
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