CTWRUBEL Posted February 12, 2007 Share Posted February 12, 2007 We have limited liquid nitrogen storage for our autologous HPC's. Patients who have excess cells collected and are not expected to have a second transplant have those cells moved to -80C. Of course we now have a request for a second transplant on one of those patients. There is only one bag left so we can't thaw to check viability. Those cells have been at -80C for about a year and a half. Has anyone run into this type of situation and how did you handle it? Link to comment Share on other sites More sharing options...
djford Posted December 20, 2007 Share Posted December 20, 2007 Depends on what cryopreservative has been used. Generally only HES?DMSO mixtures can be stored at -80 for longer peroids than 6 months. Link to comment Share on other sites More sharing options...
Franklyn Posted December 20, 2007 Share Posted December 20, 2007 You are definitely in a pickle! By the letter of the law, the physician can sign for an exception to just about anything provided he/she uses sound medical judgement and obtains informed consent from the recipient. Your choice to store at -80 almost precludes your ability to change your mind later and definitely puts the patient at risk for engraftment failure at transplant. The only way I see out of this is to have the doc sign on the dotted line and have detailed consent notes with the recipient to minimize liability.I assume there is no change of recollecting the patient? Link to comment Share on other sites More sharing options...
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