Can immediate spin be eliminated for cold agglutinins? We are going back and forth with this because immediate spin detects ABO incompatibility but the computer system is also set up to detect this.

Are you doing the immediate spin for a crossmatch or antibody screen? Well, we use the prewarm method for Cold agglutinins. We enter the results to the prewarm technique which is Negative, so the computer doesn't have a cow. Then we write in the test comments that the prewarm technique was used due to cold agglutinin, or history of cold agglutinin.

Edited June 3Jun 3 by SbbPerson

The immediate spin is for crossmatch. Thank you for your input. We are currently doing the prewarm method for colds also but our QA is concerned about prewarming so there are discussions to eliminate the I.S. phase.

At our facility, we have to do a cold adsorption IF the cold auto interferes with the reverse and/or ISXM. Since testing with "neat" plasma is our standard of practice, we would still report the XM as incompatible and send it out with a release stating the incompatibility was due to an autoantibody. We are not "allowed" to prewarm away IS reactions. 🥶 IF we prewarm - it's only if the cold has a high thermal amplitude and causes interference after 37deg incubation / antiglobulin phase...........but that's just us.........

In my opinion, if you have:

• A cold antibody (not pathological), and

• Have done the workup to show that there is no other antibody present (i.e. a clinically significant antibody such as anti-E), and

• Your LIS dictionary set up so that your reported antibody is not deemed as clinically significant

You can set it up so that the computer (electronic) crossmatch can be used.

If it is a pathological antibody, we use incompatible (i.e. Least incompatible in Meditech)