SMILLER Posted April 25, 2019 Share Posted April 25, 2019 A recent thread about homo- and hetero-zygous expression of the M antigen reminded me of something I have wondered about... Why do so many Non Specific Cold antibodies, when tested with common antibody ID panels, "mimic" anti-M? Apparently there is some moiety present on RBCs that react with a NSC from patients that are often otherwise positive for the M antigen. Yet, the pattern ofr these looks like a M reacting antibody. These seem to be always only cold reacting (IgM), and not significant, but I just wondered what is going on here. Thanks, Scott Link to comment Share on other sites More sharing options...
Malcolm Needs ☆ Posted April 25, 2019 Share Posted April 25, 2019 I haven't noticed this, I must admit, but they may be because we rarely bother to look for a specificity if the antibody is a cold auto. Link to comment Share on other sites More sharing options...
SMILLER Posted April 26, 2019 Author Share Posted April 26, 2019 We get a couple a year here. The difference is, for our records, as to whether to document it as a cold anti-M or a NSC. I just wondered what these are when they react as a M and the patient is M antigen positive. Some kind of auto-antibody I guess. Scott Link to comment Share on other sites More sharing options...
jnadeau Posted April 30, 2019 Share Posted April 30, 2019 I have noticed this too, more recently in the past couple of years - they're coming up in gel which we know enhances the "M"s but...why enough times to take notice now? We report them as a cold autoantibody mimicking anti-M. The providers never call to question this ...aren't you surprised? Link to comment Share on other sites More sharing options...
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