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The 2017 revisions were released this week. The computer crossmatch section was revised to align with the FDA guidance. "If ABO typing discrepancies exist, you should not rely on a computer crossmatch.This is particularly important if there is mixed field red cell reactivity, missing serum reactivity, or apparent change in blood type following hematopoietic stem cell transplantation.Under those circumstances, your procedures should provide for compatibility testing using serologic crossmatch techniques." I called CAP to verify that this included resolved ABO discrepancies. Our hospital had been allowing computer crossmatches for ABO discrepancies that are resolved, and I'm not sure that our BB LIS could prevent a patient with a resolved ABO discrepancy from receiving a computer crossmatch. Does your LIS prevent computer crossmatches for patients with MF reactions or weak reverses?
